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It is possible for a ModalPopupExtender to be displayed using a postback. You'll need an invisible target control.

<asp:Button runat="server" ID="btnShowModal" Text="Show"
     OnClick="btnShowModal_Click" />
<asp:Button runat="server" ID="HiddenForModal" style="display: none" />
<ajaxToolKit:ModalPopupExtener ID="Modal1" runat="server"
     TargetControlID="HiddenForModal" PopupControlID="PopupPanel" />

In your message handler in code-behind, you'll show the ModalPopupExtender:

Modal1.Show();

And in the code you're using to dismiss the Modal, call the ModalPopupExtender's Hide function:

Modal1.Hide();

Then use this method for showing a modal that displays detailed data that I retrieve from a database based on what's selected in a GridView.

Thanks for Tim to this trick :)